Many factors can influence cancer risk, from lifestyle and diet to environmental exposures, and sometimes the genes you
inherit from your parents.
Since 1990, when geneticist Mary-Claire King, Ph.D., proved that breast cancer ran down family lines, scientists have added
ovarian, uterine, colon and prostate cancer to the list of inheritable cancers, along with less common conditions including
leukemia and cancers of the kidney, brain, stomach and eyes.
“We can test for mutations in more than 140 genes linked to cancer, says Loren Yates, a licensed, board-certified genetic
counselor at Doylestown Health. “Genetic testing is not about whether or not you have the gene. It’s about whether you have
a genetic mutation — an error in your DNA language that reduces your body’s ability to protect you against certain cancer
risks,” explains Loren.
According to the National Cancer Institute, inherited genetic mutations contribute to 5 – 10 % of all cancers. “A
mutation can run in an entire bloodline, affecting siblings and the next generation, but having a genetic mutation does not
mean you’re going to get cancer,” says Loren. “It means that naturally your risk is higher. You can live your life with a
genetic mutation and never get cancer, but you can also have a negative result for all mutations and still get cancer.”
Genetic testing is optional. Anyone interested in knowing more about their personal risk for cancer can participate. Some
reasons for testing include:
- Diagnosis or strong family history of breast, prostate, ovarian or colorectal cancer
- Diagnosis or strong family history of uterine or colorectal cancer before age 65
- Ethnicity that carries a higher risk for mutation
Benefits of Genetic Testing
Awareness opens the door to early detection and prevention of cancer. “You can adjust your lifestyle, share the
information with family members and trace the genetic risk. Testing allows you to rule out family members who don’t have the
mutation and monitor those who do more closely,” Loren says.
Making a Difference
“Genetic counselors will help provide guidance in a variety of areas where we can make a difference with a patient or
patient’s family members,” says Loren. Personalized recommendations may include:
Lifestyle changes — Everyone, including people with a genetic risk for cancer, can improve their odds by
adopting healthy habits such as good nutrition and weight management, regular exercise, using sunscreen and not smoking.
Screening early and often — Early detection leads to better outcomes. A person who has an increased risk for
cancer may begin screenings earlier or have them more often than the average person. For example, a woman with the mutation for
breast cancer may begin annual screening with MRI at age 25, when the average woman has her first mammogram at age 40,
according to Loren.
Prophylactic surgery — Prophylactic surgery is removing a healthy organ as a preventive measure when the
potential to reduce cancer risk is greater than the risk of surgery. For example, a person may opt to have their stomach
removed if they discover they have inherited a mutation that points to an 80% chance of getting a stomach cancer that is
extremely difficult to detect.
Identifying the best treatment — Genetic testing can be an important part of treatment planning, as
scientists have found that cancers associated with certain genetic mutations respond better to specific medications.
Doylestown Health’s Cancer Risk and Genetics Program
Doylestown Health patients have direct access to the
Risk and Genetics Program provided through Jefferson's Sidney Kimmel Cancer Center. Call 267.885.1864 to schedule an
appointment with a genetic counselor.
Sidney Kimmel Cancer Network at Jefferson
Through its membership in the Sidney Kimmel Cancer Network at Jefferson, Doylestown Health provides the most advanced,
patient-focused care available. While most treatments can be provided effectively and appropriately at Doylestown Health, the
Sidney Kimmel Cancer Network at Jefferson offers highly specialized services available nowhere else in the region, which means
Doylestown Health patients have access to the latest research and the most advanced treatment options, first.
About Doylestown Health Cancer Institute
Doylestown Health Cancer Institute offers patients the quality care they expect from a leader in cancer diagnosis and treatment - close to home. Accredited by the American College of Surgeons Commission on Cancer, and a member of Jefferson's Sidney Kimmel Cancer Network, our board-certified physicians and oncology-certified practitioners provide comprehensive, coordinated care and services for the full range of cancer diagnoses including breast, lung, urologic, gastrointestinal and other cancers.